A youth graduate from Bahia, where he arrived in 2009, Talisca made his professional debut against Corinthians on 7 July 2013, and scored his first goal in the next match against São Paulo.

[9] On 31 October, he scored his eighth and fourth consecutive goal in Primeira Liga, in a home win against Rio Ave (1–0), keeping the top scorer lead.

[15] On 13 September, on his return to the Estádio da Luz in a Champions League group game, he scored an added-time free kick to ensure a 1–1 draw.

[18] On 8 June 2018, Talisca was loaned out to Chinese Super League side Guangzhou Evergrande Taobao for a half year, with the transfer costing €5.8 million.

[19][20] He made his debut for Guangzhou Evergrande as a starter and scored a hat-trick, including a direct free kick, to help his team win 4–0 over Guizhou Hengfeng in the league on 18 July.

[19] On 17 May 2021, Talisca joined Saudi Pro League side Al-Nassr for a reported transfer fee of $9.5 million.

[31] On 11 November 2014, Talisca was called up by Dunga to the Brazil national team to replace Lucas Moura in the international fixtures against Turkey and Austria.