Part of the sub-region of Southwestern Antioquia, it is located on the western Colombian Andes mountain range.

Andes was founded on 13 March 1852 by Pedro Antonio Restrepo Escobar.

The distance reference from Medellín city, the capital of Antioquia Department, is 117 km and it has a total area of 402.5 km2.

This town is well known for being the place where Gonzalo Arango a writer, philosopher and Antioquian journalist was born.

Andes has a tropical rainforest climate (Köppen: Af) with consistent temperatures, cool nights, and abundant rainfall.