[7] Iguodala attended Lanphier High School in Springfield, Illinois, which had produced such notable athletes as baseball Hall of Famer Robin Roberts and NBA guard Kevin Gamble.

[6][9][10] As a senior in 2002, Iguodala led Lanphier's basketball team to a runner-up finish at the Illinois High School Association Class AA state tournament.

Iguodala played AAU basketball under Larry Butler and the Illinois Warriors, the team that has featured other professional players such as Dwyane Wade and Quentin Richardson, and Duke head coach Jon Scheyer.

Iguodala visited the Arkansas campus and was impressed by their large gymnasium and the number of fans at a practice while there with his mother and father.

At Arizona, he joined future NBA players Channing Frye, Luke Walton, Mustafa Shakur, Salim Stoudamire and Hassan Adams.

After posting career totals of 594 points (9.6 ppg), 409 rebounds (6.6 rpg) and 95 steals (1.53 spg) in 62 games (34 starts), Iguodala left to enter the NBA draft.

[6] After the season, he signed with agent Rob Pelinka, co-founder of the Landmark Sports Agency, who had represented NBA All-Stars such as Kobe Bryant, Carlos Boozer, and Gerald Wallace.

[26] Iguodala went on to finish the season with averages of 18.2 points, 5.7 rebounds, and 5.7 assists, combined tallies matched or bettered only by LeBron James, Kobe Bryant, and Tracy McGrady.

In Game 1, Orlando had an 18-point lead in the fourth quarter, but Philadelphia made an amazing comeback led by Iguodala, eventually scoring a step-back, fadeaway jumper in the face of Hedo Türkoğlu with 2.2 seconds remaining to give the 76ers the win.

Philadelphia also traded veteran big man Samuel Dalembert to the Sacramento Kings for a younger center Spencer Hawes; the 76ers also acquired Andrés Nocioni in the deal.

In July 2013, Iguodala declined a five-year deal with Denver and agreed to a four-year for a reported $48 million with the Golden State Warriors.

[35] Getting the inbound pass from Klay Thompson, Iguodala turned and made the fade-away jump shot over the Thunder's Thabo Sefolosha.

[37] When playing against the Los Angeles Lakers on November 23, 2013, Iguodala strained his left hamstring late in the third quarter and went on to miss 12 consecutive games.

[39] Entering the 2014–15 season, first-year Warriors coach Steve Kerr elected to move Iguodala from the starting rotation to the sixth man reserve position, in favor of forward Harrison Barnes.

[51] In the first round of the playoffs, the Warriors faced the #8-seed Houston Rockets, and in a Game 4 win on April 24, Iguodala scored a season-high 22 points.

In the second round, Iguodala helped the Warriors defeat the Portland Trail Blazers in five games to qualify for the Western Conference Finals.

In their conference finals match-up with the Oklahoma City Thunder, Iguodala helped the Warriors fight back from a 3–1 deficit in the series to win clinch a 4–3 victory.

"[54] On November 28, 2016, Iguodala had a season-best game with 12 points, five rebounds, and five assists in a 105–100 win over the Atlanta Hawks, helping the Warriors start the season 16–2 while recording their 12th straight victory—equal to their third-longest streak in franchise history.

[62] Iguodala entered the 2017 off-season as a free agent and held meetings with numerous competing teams, including the Los Angeles Lakers, San Antonio Spurs, Sacramento Kings, and Houston Rockets.

[64] On December 11, 2017, against the Portland Trail Blazers, Iguodala played his 1,000th regular-season game, becoming one of 126 players in NBA history to accomplish the feat.

[68] In a sign of respect towards their opponent and with an increased urgency, Kerr opened the conference semifinals against Houston by moving Iguodala from the bench and starting their Hamptons Five lineup for the first time in the season.

[75][76] On July 7, 2019, Golden State traded Iguodala along with a protected first-round draft pick to the Memphis Grizzlies for Julian Washburn.

Iguodala's decision to remain away from the team drew backlash from teammates, notably Dillon Brooks and Ja Morant, who said his refusal to play was disrespectful.

[89][90] Iguodala went on to win his fourth championship after the Warriors defeated the Boston Celtics in six games of the 2022 NBA Finals, in limited playing time.

On September 23, 2022, Iguodala re-signed with the Warriors on a one-year, fully guaranteed, $2.9 million contract (the veteran's minimum) and announced his decision to retire after the season.

[91] After missing the first 39 games due to a hip injury, Iguodala made his season debut on January 8, 2023, in a 115–101 loss to the Orlando Magic.

His partnership with entrepreneurs in San Francisco's Silicon Valley has led to an annual event tagged Players Technology Summit.

In this role, he works on behalf of current members to ensure their rights are protected and their collective value is fairly compensated as the heart and soul of the NBA, both on the court and as ambassadors of the game worldwide.

His passion for making lasting and positive changes to the game – with fellow NBA players in mind – continues today in his work as the executive director of the NBPA.

[112] On November 17, 2024, Iguodala joined popular internet sensation Kai Cenat in support of his "Mafiathon 2" a 30 day subathon in attempt to break the Twitch subscriber world record.