He was ready to step up to his biggest challenge against big American puncher Allan Green (25–1, 18 KOs), with the fight scheduled to take place on February 2, 2008, on HBO.

On March 20, 2008, at the HP Pavilion in San Jose, California, Ward defeated Rubin Williams by seventh-round TKO.

Ward faced Jerson Ravelo on June 20, 2008, in Georgetown, Cayman Islands, for the vacant regional NABO super-middleweight title.

[18] The Ring Top 10 ranked super-middleweight Allan Green (25–1, 18 KOs) was selected as his replacement and challenged Andre Ward on June 19.

[19][20] Ward, defending the WBA super middleweight title, outclassed an opponent who spent most of the fight with his back against the ropes.

Though the 30-year-old gamely fought on, the knockout he needed to win never appeared remotely likely and he looked a spent man by the end as he picked up the second loss of his 31-fight pro career.

[21][22] Ward was exempt from the final preliminary fight in the Super Six because he had already secured a number one position in the elimination rounds and his designated opponent (Andre Dirrell) had dropped out of the tournament.

[24] Fighting in front of his hometown crowd as part of a dual-site co-main event, Ward didn't land many big shots but repeatedly hit Bika with a stinging left jab that the challenger was unable to counter.

[29] In the post fight interviews, Abraham said through a translator, "I started well, and I thought I did good the first three rounds He didn't hit me, and I was blocking a lot of his shots.

An MRI later revealed that Ward injured his lead left hand on which he relied for landing hooks to Froch's head.

Ward noted extreme pain in the sixth round of the fight as well as one week prior, though the initial X-ray came back clear.

[38] Ward's next fight was announced on June 22, 2012, to take place at the Oracle Arena in Oakland, California on September 8, 2012, against The Ring and lineal light heavyweight champion Chad Dawson.

At the press conference, he said that it was his desire to drop down in weight and challenge Ward rather than fight lesser-known opponents at light heavyweight.

Ward defended his WBA and Ring titles against unbeaten Edwin Rodríguez in Ontario, California in November 2013 with a wide unanimous decision.

[51][52] Dan Goossen died of complications from liver cancer in September 2014, leaving the future of Andre Ward's boxing career even further in doubt.

[62] On November 12, 2015, in advance of his upcoming move up to the light heavyweight division, Ward vacated his WBA super middleweight title.

Ward originally claimed the belt in November 2009 with a victory over long-time champion Mikkel Kessler in his opening fight of the Super Six tournament.

[63] Boxing Scene reported In January 2016, Ward's light heavyweight debut was set against Cuban boxer Sullivan Barrera (17–0, 12 KOs) at the Oracle Arena.

En route to a wide unanimous decision victory, Ward dropped Barrera to the canvas in the third round as he turned a left hook while on the ropes.

Barrera was also dropped in the eighth round from a body shot, but referee Raul Caiz Sr. saw it as a low blow and as a result deducted a point from Ward.

Ward dictated the pace for the vast majority of the bout, showcasing good strength and ring generalship against Barrera.

[71] In front of 8,653 hometown fans, Ward unanimously outpointed Brand to claim the vacant WBO International light heavyweight title.

[75] Ward fought the unified IBF, WBA (Super) and WBO light heavyweight champion Sergey Kovalev at the T-Mobile Arena on November 19, 2016.

"[77] Ward received Kovalev's WBA (Super), IBF, and WBO light heavyweight titles and became a two-division world champion.

Paulie Malignaggi noted the high degree of difficulty both fighters faced that night and doubted the prospect of a one-sided affair in the case of a rematch.

[91] On April 4, Roc Nation Sports and Main Events confirmed that terms were agreed for the rematch to take place on HBO PPV.

[98] Tony Weeks stopped the fight, with Kovalev sitting on the middle rope, visibly hurt from the low blows he was subjected to.

[111] His trainer, Virgil Hunter, says Ward harnesses his speed and ring intelligence to control distance and pace in fights while maintaining high punch accuracy and counterpunching skills.

[112] A natural left-handed fighter who boxes in an orthodox stance, Ward's best punches typically come from the lead left, including a sharp, piston-like jab, which he shoots to the body as well as the head.

He attributes his self-described "formless" style to years of studying Roy Jones Jr., Bernard Hopkins, and Floyd Mayweather Jr.[113] Ward also makes effective use of the jab to the body while out of punching range.