Bresciani was born Dušan Brešan to a Slovene family in Tolmino (at the time part of the Province of Gorizia in Italy but now a city in Slovenia).

Entirely self-taught, Bresciani began his career as a commercial artist designing furniture for an architect in Milan while commuting from Pavia.

[5][6] In late 1950 Bresciani emigrated to Australia, eventually settling in Sydney in 1951 where he worked for Atlas Publications, illustrating stories for Squire: A Man's Magazine and producing covers for their pulp fiction magazines and their comic books Flynn of the FBI and The Wraith as well as drawing whole issues of The Ghost Rider and Sergeant Pat of the Radio Patrol.

[3][4] In the early 1970s Bresciani, who had recently remarried, returned to Europe, working as a cartoonist and illustrator in Spain and Germany and extending his career to film.

He worked as an animator, layout artist, and art director for Hanna-Barbera in Europe and later in Sydney when he returned to Australia.