Born in Pescara, Camplone grew up playing with his hometown club, for whom he spent nine full seasons as a senior, amassing a total 188 games (52 of which at Serie A level).
Camplone started his career as trainer at amateur Promozione level, guiding Abruzzo club Penne.
In November 2012 he was named head coach of Perugia, which he led to second place in the Serie C1/B league and subsequent elimination in the promotion playoff semifinals to Pisa.
Following this defeat, he was dismissed from his position, only to be renamed as Perugia boss two months later after his replacement Cristiano Lucarelli was sacked before the first matchday of the season.
[1] On his second tenure at Perugia, Camplone managed to lead the Grifone to win the 2013–14 Lega Pro Prima Divisione title and get promoted to Serie B.