Kremer began her career in 1982 as the sports editor of the Main Line Chronicle in Ardmore, Pennsylvania, the state's largest weekly newspaper.

Upon completing a story on NFL Films, the television production arm of the National Football League, Kremer's mother urged her to apply for a position.

She received an Emmy Award nomination in 1986 for writing and editing the NFL Films special "Autumn Ritual."

While at NFL Films, she served as contributing reporter to the Philadelphia Eagles Pre-Game Show on WIP-AM In 1989, she became ESPN's first female correspondent.

Kremer has been a correspondent for HBO's Real Sports with Bryant Gumbel since 2007, having contributed a host of critically acclaimed profiles and features to the Emmy Award-winning newsmagazine show.

Her 2016 investigation into sexual assault in Bikram Yoga, which was named as one of the ten most shocking stories of the year by Metro.

[6] During her time at Real Sports with Bryant Gumbel, she interviewed Robert Kraft, Kobe Bryant, Urban Meyer, Pete Carroll, Phil Jackson, Lane Kiffin, Barrett Robbins, DeMaurice Smith, Bill Parcells, Joakim Noah, Jim Harbaugh, and John Harbaugh.

She interviewed Johnny Jolly during his prison sentence for drug abuse charges and return to the field with the Green Bay Packers.

Airing in prime time, the weekly show featured a rotating group of female panelists discussing all topics and news in sports.

She was presented with the award at the 2018 Enshrinement Ceremony on Saturday, August 4 in the Tom Benson Hall of Fame Stadium.

[13] She was presented with the PRISM Award in 2005 for her story on NFL defensive player Dexter Manley's substance abuse and addiction.

Kremer has spoken at events for Amarantus Bioscience, Citi, Goldman Sachs, First Republic Bank, Fidelity, NFL All-Access, The Boston Group, and the Philadelphia Eagles.