Lo Cicero was included in Italy's squad for the 1999 Rugby World Cup but did not see any action and had to wait until the following year to make his international debut.

It came against England in 2000 when he had the difficult task of filling the gap left by the Azzurri prop and captain Massimo Cuttitta.

He was named in the BBC's dream XV at the 2004 Six Nations Championship and was part of the Barbarians squad to take on New Zealand later that year.

Lo Cicero was the only European player to receive a call, and he capped the feat by scoring a try.

He was also selected for the 2013 Barbarians squad to play in Hong Kong against the British and Irish Lions and England.