In 2013, Radrizzani led MP & Silva's negotiations to secure the Premier League's broadcast rights in 51 territories, including the Middle East.

Radrizzani was also responsible for leading rights distribution deals with Roland Garros, Bundesliga, La Liga, Ligue 1 among others.

[3] In January 2017, through Aser, Radrizzani made an investment for 50 per cent of the share capital of Leeds United, making him co-owner of the club.

[12] Aspire own Spanish team Cultural Leonesa who have seen Leeds players Yosuke Ideguchi and Ouasim Bouy both join them on loan as part of the unique partnership.

[17] On 4 February 2018, head coach Thomas Christiansen was dismissed by Radrizzani, despite a promising start to his reign, after a poor run of results and with the team tenth in the table.

[18] On 6 February 2018, Radrizzani appointed Barnsley manager Paul Heckingbottom as the new head coach of Leeds United on an 18-month contract to replace Christiansen.

[19][20] On 7 March, towards the end of Leeds' 0–3 defeat against Wolverhampton Wanderers, just before the final whistle, Radrizzani in a series of Twitter posts, questioned the legality and fairness of the competition.

[23] However, the tour announcement drew criticism nationally and from MP's and Amnesty International due to the political situation in the country.

On 16 July 2018 Radrizzani revealed that “Unfortunately, the short time available to perform detailed and thorough due diligence checks, force us reluctantly to abandon this idea and challenge.”[32] On 31 July, Radrizzani signed striker Patrick Bamford to Leeds for £7 million (rising up to £10 million), the move representing the highest fee Leeds had spent on a player since Robbie Fowler's move to the club in 2001.

[33][34][35] After the sale of promising young player Ronaldo Vieira to Italian side Sampdoria on 1 August, Radrizzani defended the sale to supporters by saying “We cannot buy players and never sell players.”[36] During the 2018–19 season, Leeds finished the regular season in third place after dropping out of the automatic promotion places with three games left after a defeat to ten-man Wigan Athletic on 19 April,[37] Leeds qualified for the playoffs versus sixth-placed Derby County, winning the first leg of the playoffs 1–0 win at Pride Park, but lost the home leg 2–4 with Leeds also down to ten men after the dismissal of Gaetano Berardi.

[38] The loss saw Derby progress 4–3 on aggregate to the final against Aston Villa and Radrizzani's club narrowly miss out on promotion.

[38] In August 2019, Radrizzani was one of the main participants in the Leeds United documentary 'Take Us Home' documenting the 2018–19 season on Amazon Prime, featuring in all episodes.

[58] Radrizzani is also founder and chairman of the Play for Change Foundation, a charity that runs sport and education programmes for children both internationally and in Italy, his home country.

[60] Jinxin, a joint venture between China Everbright Group and Beijing Baofeng Technology, acquired 65% of MP & Silva in 2016.