(2011), Shadow Dancer (2012), Oblivion (2013), Birdman (2014), Nocturnal Animals (2016), Battle of the Sexes, The Death of Stalin (both 2017), Mandy, Nancy (both 2018), The Grudge, Possessor (both 2020), and To Leslie (2022).

Riseborough was born on 20 November 1981 in Newcastle upon Tyne, the daughter of Isabel, a secretary and beautician, and George, a car dealer.

[8] She co-starred in the acting ensemble of the Alejandro González Iñárritu's showbusiness drama film Birdman (or The Unexpected Virtue of Ignorance), which won the Oscar for Best Picture at the 87th Academy Awards.

[11][12] She acted as Emma Stone's love interest in the biographical sports film Battle of the Sexes, based on the 1973 tennis match between Billie Jean King and Bobby Riggs.

[20] Riseborough starred in the international cocaine trade drama ZeroZeroZero, an eight-part series adapted from the book by Roberto Saviano, which had its debut on Sky in the UK and Amazon Prime in the US in 2020.

[21][22] She starred in Possessor—written and directed by Brandon Cronenberg—as Tasya Vos, an agent for a secretive organization who uses brain-implant technology to inhabit other people's bodies, driving them to commit assassinations for the benefit of high-paying clients.

Numerous celebrities praised her performance publicly and on social media, and hosted screenings during the voting period for the Academy Award nominations in January 2023.

In 2023, she acted opposite Kate Winslet portraying Vogue editor Audrey Withers in the biographical war drama Lee which premiered at the Toronto International Film Festival.

In 2024, Riseborough acted opposite Winslet again, portraying the latter's character's right-hand woman, in the HBO political satire miniseries The Regime, for which she earned a nomination at the inaugural Gotham TV Awards for Outstanding Performance in a Limited Series.