She began her career as a child actress and subsequently became popular in the 1980s and 1990s for her roles in telenovelas, such as Estrellita mía, Celeste, Antonella and Perla negra.
[1] In 1970, she started to play in the series Alta comedia and won the prestigious Martín Fierro Award for 1971 in the Revelación category, an equivalent of the Best New Artist.
[2] In 1972, she appeared in her first film, Había una vez un circo, alongside a trio of popular clowns called Los Payasos de la Tele.
The telenovela was a story of a young woman experiencing amnesia and being raised as a gypsy, but failed to repeat the success of Del Boca's previous series.
In 2000, she returned to film in the romantic comedy Apariencias directed by Alberto Lecchi, and from 2001 to 2002, she played the main character in the TV series El sodero de mi vida.
[3] In 2005, she was honoured with a special Martín Fierro Award[4] and played the title role in the telenovela Sálvame María on Canal 9 which was filmed entirely in San Luis Province.
In 2007, she appeared in one episode of the series Mujeres asesinas and joined the judging panel of a TV show selecting the cast for the Argentine version of High School Musical in which she also played a small role.
In 2008, she hosted a popular TV show La mamá del año which revolved around motherhood and joined the series Por amor a vos as a recurring character.
[5] In autumn Del Boca premiered Tiempo de pensar, a TV series she co-produced and starred in, tackling the issue of gender violence, stereotypes and female representation in the media.
[7] In 2019, she appeared in another theatre play, Brujas, with Leonora Balcarce, Andrea Bonelli, Romina Ricci and Viviana Saccone, which was a critical and commercial success.
[9] From 1988 to 1995 Andrea's partner was Argentine filmmaker Raúl de la Torre, and from 1995 to 1997 she was involved with American health care policy expert Jeffrey A. Sachs.