St. Mary's (Central Yupik: Negeqliq) is a city in Kusilvak Census Area, Alaska, United States.

The adjacent village of Andreafsky (historically known as Clear River) joined with St. Mary's in 1980.

Within Saint Mary's there are two federally-recognized tribes the Algaaciq Native Village and the Yuupiit of Andreafsky.

Saint Mary's first appeared on the 1960 U.S. Census as an unincorporated village.

28.5% of all households were made up of individuals, and 2.2% had someone living alone who was 65 years of age or older.