Her Sfeir-Semler Gallery has branches in Hamburg, Germany and Beirut, Lebanon, and both locations represent artists working in the field of conceptual art with a preference on political subjects.
"[4] In April 2005, on the 20th anniversary of the opening of her German gallery, she made her Beirut exhibition début with "Flight 405", a group show of work by The Atlas Group/Walid Raad, Elger Esser, Alfredo Jaar, Emily Jacir, Amal al Kenawy, Till Krause, Hiroyuki Masuyama, Michelangelo Pistoletto, and Akram Zaatari.
Since then she has mounted numerous exhibitions including the first one-person-shows in the Middle East by Walid Raad (2008), Akram Zaatari (2009), Wael Shawky (2011),[5] Marwan (2009), Yto Barrada (2010), Etel Adnan (2010), Mounira al Solh (2011), Hassan Sharif (2012), and Gabriel Kuri (2012).
Her Beirut gallery has hosted diverse curatorial projects including a group show of young Egyptian artists "Out of Place"(2006), curated by William Wells of the Cairo Townhouse Gallery, Catherine David’s "In the Middle of the Middle" (2008),[6] Bidoun Magazine’s show "NOISE" (2009) by Negar Azimi and Babak Radboy,[7] "Au Delà des Images (Beyond Images)" (2006) with works of the Fond National d'Art Contemporain, France, curated by Jean Marc Prévost & Akram Zaatari, and "HomeWorks" (2008), a recurring forum on Contemporary Art based in Beirut organized by Christine Tohmé, director of Ashkal Alwan.
[citation needed] Sfeir-Semler Gallery also represents established European and American artists including Robert Barry, Elger Esser, Ian Hamilton Finlay, Hans Haacke, Günter Haese, Sol LeWitt, Timo Nasseri, Michelangelo Pistoletto, Ulrich Rückriem, Christine Streuli, therefore nurturing a cross-cultural link between Western and Middle Eastern contemporary art practices.