Giménez signed with the New York Mets of Major League Baseball (MLB) as an international free agent in July 2015.

[4] He spent the 2018 season with both the St. Lucie Mets and the Binghamton Rumble Ponies, batting .281/.347/.409 with six home runs, 46 RBIs, and 38 stolen bases in 122 total games between the two clubs.

[10] On July 29, Giménez made his first start, and recorded his first career hit off of Boston Red Sox pitcher Nathan Eovaldi, a single, in the second inning.

[13] On January 7, 2021, the Mets traded Giménez, Amed Rosario, Josh Wolf, and Isaiah Greene to the Cleveland Indians for Francisco Lindor and Carlos Carrasco.

[21] On March 30, Giménez signed a seven-year major league contract with the Guardians worth $106.5 million.

[22] On April 12, 2023, a relay throw to home plate by Giménez struck the head of umpire Larry Vanover, who was hospitalized with non-life threatening injuries.