He was the executive producer and showrunner of AMC’s Fear the Walking Dead alongside Ian B. Goldberg.

In 2009 he joined the writing staff of Joss Whedon's philosophical science-fiction series Dollhouse.

[1] After the cancellation of Dollhouse, he wrote an episode of the Starz historical epic Spartacus: Blood and Sand before joining the staff of The Vampire Diaries on The CW.

[3] In summer 2011, Chambliss joined the ABC fantasy series Once Upon a Time as a writer and co-producer.

[4] On April 14, 2017, Andrew Chambliss and Ian B. Goldberg were announced as joint showrunners for the 4th season of Fear the Walking Dead[5]