[2] The county was organized January 29, 1841, and named for Andrew Jackson Davis, a lawyer and prominent citizen of St.

The Platte County Railroad (CB&Q) reached there in 1860, and today's Chicago, Great Western in the late 1880s.

The town grew as a shipping point and trading center in the post Civil War era.

Andrew County's glacial plains support fertile livestock, grain, and fruit farms.

Members of fur trader W. Price Hunt's 1811 Astorian expedition wintered near the river's mouth as well.

The most predominant denominations among residents in Andrew County who adhere to a religion are Southern Baptists (38.62%), United Methodists (21.14%), and Disciples of Christ (9.86%).

Andrew County, along with the rest of the state of Missouri, is represented in the U.S. Senate by Josh Hawley (R-Columbia) and Roy Blunt (R-Strafford).

Like most rural areas throughout northwest Missouri, voters in Andrew County generally adhere to socially and culturally conservative principles which tend to influence their Republican leanings.

On the Democratic side, former Vice President Joe Biden (D-Delaware) both won statewide and carried Andrew County by a wide margin.

Incumbent President Donald Trump (R-Florida) faced a primary challenge from former Massachusetts Governor Bill Weld, but won both Andrew County and statewide by large margins.

Businessman Donald Trump (R-New York) narrowly won the state and Andrew County.

Senator Rick Santorum (R-Pennsylvania), who finished first in the state at large, but eventually lost the nomination to former Governor Mitt Romney (R-Massachusetts).

Incumbent President Barack Obama easily won the Missouri Democratic Primary and renomination.

In 2008, the Missouri Republican Presidential Primary was closely contested, with Senator John McCain (R-Arizona) prevailing and eventually winning the nomination.

Despite initial reports that Clinton had won Missouri, Barack Obama (D-Illinois), also a Senator at the time, narrowly defeated her statewide and later became that year's Democratic nominee, going on to win the presidency.