Andrea "Andrew" DeLuca, M.D., is a fictional character from the medical drama television series Grey's Anatomy, which airs on ABC in the United States, and is portrayed by Giacomo Gianniotti.

Throughout his time on the show, Andrew formed personal connections with many of the attending surgeons, a rare development among interns and residents.

Despite the initial challenges, the lack of strict direction gave Gianniotti the freedom to "fill in the blanks" and develop the character on his own.

After operating in a manic state and causing the deaths of four patients, Vincenzo used his connections and wealth to avoid prosecution, prompting Andrew's mother to leave with him.

[7] In the penultimate episode of Grey's Anatomy's eleventh season, titled "Time Stops", Dr. Andrew DeLuca makes his first appearance.

[8] He also briefly dates Maggie Pierce (Kelly McCreary), the Chief of Cardiothoracic Surgery, but ends the relationship due to feeling professionally intimidated by her.

[9] Later, Andrew develops feelings for Jo Wilson (Camilla Luddington) and takes her home from a bar when she is too drunk to drive.

[12] Andrew later becomes a surgical resident, and his ex-girlfriend, Sam Bello (Jeanine Mason), joins Grey Sloan Memorial as an intern.

[7][9] His sister, Carina DeLuca (Stefania Spampinato), also joins the hospital staff and begins dating Arizona, much to Andrew's discomfort.

[14] Afterward, a heartbroken Andrew drunkenly kisses Meredith Grey (Ellen Pompeo) at Jo and Alex's wedding, eventually realizing his feelings for her are real.

Though they briefly reconcile, Andrew breaks up with Meredith for good when she expresses concern that he might be showing signs of mania, possibly due to bipolar disorder.

Despite his worsening condition, Andrew makes a significant medical diagnosis, identifying Richard Webber’s (James Pickens Jr.) cobalt poisoning, which alters his career trajectory.

Farley cited the fact that DeLuca remained on Grey's Anatomy after multiple seasons as evidence that the "Rhimesian jury" had ruled in his favor, confirming his likability.