[5] Meredith is assigned to work under Miranda Bailey, the only character developed with a racial description in mind, who is portrayed by Chandra Wilson.
The other interns working with Meredith under Bailey are Cristina Yang, George O'Malley, Izzie Stevens, and Alex Karev played by Sandra Oh, T.R.
Oh was initially brought to play the character of Bailey, but she was pressed to read for the role of Cristina instead at the audition.
[11] Burke departs after the third season, and is replaced by Erica Hahn, played by Brooke Smith, who leaves the show during the fifth.
Following O'Malley's death and Stevens' departure, Jesse Williams and Sarah Drew joined the cast as new residents from Mercy West Jackson Avery and April Kepner both having made their series debuts as recurring characters in the sixth season.
Scorsone guest-starred as Dr. Amelia Shepherd in the seventh and eighth seasons and was a main character on Private Practice.