Notable works includes writing or producing episodes of 30 Rock, Community, Suburgatory, and Brooklyn Nine-Nine.
Guest wrote episodes for the series Community including: "Advanced Criminal Law" (2009), "Messianic Myths and Ancient Peoples" (2010), "Romantic Expressionism" (2010), "Advanced Dungeons & Dragons" (2011), and "A Fistful of Paintballs" (2011).
He is set to co-write a film, along with series creator Dan Harmon, based on Community for Peacock.
In 2022, it was announced Guest was hired as head writer for the upcoming Marvel Studios television series Wonder Man, based on the comic book character of the same name.
[2] He was nominated for the Writers Guild of America Award for Best Comedic Series at the February 2009 ceremony for his work on the third season of 30 Rock.