Andrew Hutchins Mickle (October 25, 1805 – January 25, 1863) was the 67th Mayor of New York City from 1846 to 1847.

As a young man he married the daughter of George B. Miller, a tobacco dealer, afterwards working in his father-in-law's firm.

He expanded the firm and its product line, and became wealthy as a result.

[2] A Democrat affiliated with the Tammany Hall organization, in 1845, he won election as Mayor of New York City, taking advantage of a four-way race to win with a plurality.

After serving one two-year term Mickle declined to run for reelection and returned to his business interests.