While at Berkeley, Huberman approached Carla J. Shatz to serve as his doctoral advisor; however, she declined the offer, concerned that he had a limited background in molecular and cellular biology and that she would be moving her lab to Harvard.

[12] During his postdoctoral work at Stanford, Huberman developed genetic tools to study the visual system and contributed to Thrasher.

[7] The lab gained attention in 2016 for using virtual reality (VR) to stimulate retinal neuron regrowth.

[7][13][14] The lab also researched non-pharmacological interventions for anxiety disorders, including VR exposure to controlled stressors and breathing techniques.

[5] Huberman was introduced to Robert Mohr in 2019, a New York-based health and fitness publicist who produced "The Fight with Teddy Atlas," a boxing podcast.

Mohr facilitated Huberman's appearances on major podcasts, including those hosted by Joe Rogan and Rich Roll.

[3] Jonathan Jarry from the Office for Science and Society has questioned Huberman's promotion of "poorly regulated" dietary supplements.

According to Jarry, The Huberman Lab podcast has been sponsored by "companies offering questionable products from the perspective of science-based medicine".

[20] However, Berson also noted that the research community did not always approve of Huberman's monetization of his podcast through sponsors and partnerships.

His promotion of unregulated health supplements has been particularly controversial, as these products often have little scientific evidence supporting their effectiveness.

[6] In a 2023 GQ article, Huberman said that he is not a "sunscreen truther" – a term used to describe anti-sunscreen conspiracy theorists.