He spent his childhood in Ann Arbor, Michigan and Peterborough, Ontario, attended Lakefield College School as a boy, and studied architecture at Carleton University, Ottawa.
During his studies in 1989 he won the AIA/ACSA Research Council-Otis Elevator International Student Competition for his mixed-use commercial, retail and residential design for a development in historic London.
In 1992 he was co-commissioned by the 'Werkstatt Industrielles Gartenreich' of the Bauhaus Dessau Foundation to make a documentary video about the 'Kulturpalast Bitterfeld', a Socialist Utopian model project of the German Democratic Republic, built in 1954.
Hull's films from this time explored the genres of horror and comedy, the real and the fictional; they also documented and questioned the strained political and social transformations taking place in Germany after the fall of the Berlin Wall.
In Dessau he made Earworm, a forty-three-minute film funded by both German and Canadian Arts Councils that told the story of a group of anarchist karaoke enthusiasts gripped by a mysterious virus that causes an addiction to techno music and a taste for sucking the inner ear out of unsuspecting victims.
In 2008 Andrew re-located to London, England, to be with his life partner, contemporary artist and painter, Shaan Syed, and to begin production on his first feature film, Siren, co-written with Canadian-born, US-based screenwriter Geoffrey Gunn.
The piece was performed by thirty of the UK's most prominent dance artists and was made in response to an invitation to create a new site-specific work that spoke to the distinct architecture of Nicholas Hawksmoor's Christ Church, Spitalfields in the East End of London,[13] the neighbourhood where Hull lived and died from 2008 to 2010.
London-based Dutch contemporary artist, Magali Reus, in the final credit of her 2010 video work Finish, dedicated the piece to Andrew Mackenzie Hull.
The short work was premiered at Galerie Fons Welters in Amsterdam in July 2010 as part of a solo exhibition of sculpture and video titled Weekend and featured five athletes/actors racing against the backdrop of an ocean beach.