During his reign, he was constantly at war with the Lombards and he allowed Gaeta, his vassal, to move towards independence under its own consuls.
It was supposed to be a five-year armistice during which merchants of the various coastal Greek cities were free to travel unmolested through the Principality of Benevento.
Between July and August 839, Sicard died and Andrew, ever fearful of warring Lombards, called on the aid of Lothair I, King of Italy, who sent one Contardus to Naples.
Fearful of Contardus, Andrew promised him his daughter Eupraxia, the widow of Leo, in marriage.
Andrew, however, put off the marriage until, in March 840, Contardus rose against him and had him killed, usurping his place as he had done to Leo.