The Andrew Johnston Big Scrub Nature Reserve is a protected nature reserve in the Northern Rivers region of New South Wales, Australia.

A subtropical jungle remnant of the Big Scrub, the 21-hectare (52-acre) reserve is approximately 19 kilometres (12 mi) northeast of Lismore.

[3] The Reserve is the largest and most important of the remnants of the Big Scrub.

[4] Significant rainforest tree species include white booyong, rosewood, long jack, red bean, koda, cudgerie, white cedar and black bean.

As at most of the Big Scrub remnants, large Moreton Bay figs are prominent at this reserve.