One of the most highly touted amateur prospects during his collegiate playing career with Stanford,[2][3] Luck won the Maxwell, Walter Camp, and Johnny Unitas Golden Arm awards as a senior.

[17] Sources: After accepting an athletic scholarship to attend Stanford University, Luck played for coaches Jim Harbaugh and David Shaw with the Cardinal from 2008 to 2011.

Playing in a run-oriented offense featuring Heisman Trophy runner-up Toby Gerhart, Luck threw for 2,575 yards.

[37] In September 2010, before Luck's sophomore season, Sports Illustrated's Tony Pauline considered him "the most NFL-ready of all the draft-eligible quarterback prospects.

[44][45] Throughout the 2011 NFL season, some fans called for their teams to try to lose their remaining games (or "Suck for Luck") in order to improve their chances at the first pick in the draft.

[48] Ending speculations on April 24, Colts general manager Ryan Grigson announced the team would take Luck as the first pick.

[53] The deal made Luck the fourth starting quarterback for the Colts in the past two NFL seasons,[54] following Kerry Collins, Curtis Painter, and Dan Orlovsky.

After throwing a touchdown to fellow rookie LaVon Brazill, Luck and the Colts were able to get the ball back to the Lions' 14-yard line, facing a 4th down with four seconds left.

[67] On October 6, Luck led the Colts to a 34–28 win over the then-undefeated Seattle Seahawks in his first game against fellow sophomore quarterback Russell Wilson.

Luck also recorded his ninth career fourth-quarter comeback in the win, handing Seattle their first regular-season loss since November 25, 2012.

[68] The Colts traveled to San Diego to face the Chargers for a Week 6 Monday Night Football match, the first of Luck's career.

[69] In week 7, Peyton Manning made his return to Lucas Oil Stadium to face Luck on NBC Sunday Night Football.

[75] Luck played his first NFL home playoff game on January 4, 2014, against the fifth-seeded Kansas City Chiefs in the Wild Card Round.

After the Colts fell back by 28 points, he led a historic comeback, capping the game with a 64-yard touchdown pass to T. Y. Hilton to take the lead for the first time, 45–44.

The Colts defense would then deny Alex Smith a chance to get Kansas City within field goal range to end the game.

[82] In a Week 2 loss against the Philadelphia Eagles, Luck threw for 3 touchdowns, passing Jim Harbaugh for fourth on the Colts' all-time list.

[83] Looking to avoid losing three consecutive games for the first time in his career, Luck completed 31 of 39 passes for 370 yards and 4 touchdowns against the Jacksonville Jaguars to win 44–17 in Week 3.

[84] In a Week 4 win against the Tennessee Titans, Luck became the first quarterback in NFL history to throw for 370 yards or more, 4 touchdowns, and have a completion percentage 70 percent or above in consecutive games.

[88] Luck continued his excellent play in Week 7 against the Cincinnati Bengals, passing for over 300 yards for the 5th consecutive game, tying the Colts record set by Peyton Manning.

[90] Luck broke his single-season touchdown mark in the Colts Week 9 game against the New York Giants, throwing four to bring his total to 26.

[98] In the Colts' Wild Card Round game against the Cincinnati Bengals, Luck completed 31 of 44 passes for 376 yards and a touchdown, leading the team to a 26–10 victory.

Backup Matt Hasselbeck played in his place and led the team to a 16–13 overtime win over the Jacksonville Jaguars, followed by a 27–20 Thursday Night Football victory over the Houston Texans.

[106] On November 10, it was announced that Luck would miss 2–6 weeks with a lacerated kidney and partially torn abdominal muscle, suffered during the fourth quarter of the Colts 27–24 win over the previously undefeated Denver Broncos two days prior.

[116] Following surgery on his shoulder during the off-season, Luck was held out of training camp and the preseason, and it was announced he was to miss regular season games.

[117] Scott Tolzien started for the season opener against the Los Angeles Rams, and the newly acquired Jacoby Brissett took over as the starter in Week 2 against the Arizona Cardinals.

The win put the Colts in position for a chance to earn a Wild Card playoff berth the following week in their matchup with the Titans.

[138] Luck and the Colts upset the AFC South division champion Houston Texans in the Wild Card Round by a score of 21–7.

[146][147] After very few public appearances and no interviews following his retirement, an ESPN article written by Seth Wickersham in December 2022 went into more detail about Luck's decision.

[168] In 2013, Luck appeared on the comedy series Parks and Recreation as himself alongside teammates Reggie Wayne, Anthony Castonzo, Robert Mathis, and Adam Vinatieri during the show's fifth season.

[169] Starting in 2015, a parody Twitter account portrays Luck as an American Civil War-like soldier commenting on his career.