[10][11][12][13][14][15] Mahomes played college football for the Texas Tech Red Raiders, winning the Sammy Baugh Trophy as a junior after leading the FBS in passing yards and total touchdowns.

[30][33] Mahomes was also a top prospect for the 2014 Major League Baseball draft, but he was not expected to be selected high due to his commitment to Texas Tech.

[74] Mahomes played most of the game and helped lead the Chiefs to a 27–24 win, completing 22 of 35 passes for 284 yards and one interception in his NFL debut.

[87] During Monday Night Football against the Los Angeles Rams in week 11, Mahomes finished with 478 passing yards, six touchdowns, and three interceptions as the Chiefs lost 54–51.

[105] For the second consecutive season, Mahomes was named AFC Offensive Player of the Month for September after leading the Chiefs to a 4–0 start (10 passing touchdowns with no interceptions).

Mahomes asked his coaching staff to call the play Jet Chip Wasp, and successfully completed a deep pass to Tyreek Hill for 44 yards.

[136] In 2020, Sports Illustrated named him one of their Sportspeople of the Year for his activism following the murder of George Floyd and his encouragement for people to vote in the 2020 presidential election.

'"[143] In the AFC Championship in a highly anticipated matchup against the Buffalo Bills and their dual-threat quarterback Josh Allen, Mahomes threw for 325 yards and three touchdowns,[144] while leading the Chiefs to a 38–24 victory and their second consecutive Super Bowl appearance.

[145] The Chiefs hosted the conference championship game for the NFL-record-tying third consecutive year, the other instance was during Andy Reid's tenure with the Philadelphia Eagles.

[146] In Super Bowl LV against the Tampa Bay Buccaneers, Mahomes threw for 270 yards and two interceptions in the game as the Chiefs lost 31–9.

[148] The Chiefs' injury-ravaged offensive line was no match for the Buccaneers' pass rush defense, as Mahomes was pressured on a Super Bowl record 29 of 56 dropbacks while also being sacked three times and hit twice.

[149][150] Despite the pressure, Mahomes still managed to throw several long accurate passes that were dropped by their intended targets resulting in incompletions: one fourth-quarter highlight showed Mahomes throwing a sidearm pass, despite being tripped by Buccaneers defensive end William Gholston, that ultimately hit the facemask of receiver Darrel Williams and was dropped.

[151] Three days after the Super Bowl, Mahomes underwent surgery to repair a turf toe injury he suffered in the divisional round game against the Browns.

[158] In the Chiefs' week 9 victory over the Green Bay Packers, Mahomes threw for 166 yards, which was a career low in games he finished.

[191] In the AFC Championship game, the Chiefs defeated the Cincinnati Bengals, ending a three-game losing streak (including playoffs) to the team, to advance to their third Super Bowl in four seasons.

[192] Against the Philadelphia Eagles in Super Bowl LVII, Mahomes re-aggravated his ankle late in the second quarter as the Chiefs went into halftime trailing by 10.

However, Mahomes stayed in the game and led Kansas City to a touchdown on their first three drives of the second half, leading the Chiefs to a 38–35 win over the Eagles.

[194] He also joined Tom Brady and Joe Montana as the only quarterbacks to win multiple regular season and Super Bowl MVPs.

[196] On September 18, 2023, the Chiefs and Mahomes agreed to restructure his contract, giving him $210.6 million between 2023 and 2026, the most money in NFL history over a four-season span.

[197] In Week 4 against the Jets, Mahomes passed for his 200th career touchdown, becoming the fastest player in NFL history to reach that milestone, having done so in just his 84th start.

[208] The Chiefs' playoff run began with a commanding 26–7 win over the Miami Dolphins at home in subzero temperatures in the wild card round.

[209] The next week, Mahomes played his first career road playoff game, scoring a narrow 27–24 win over the Buffalo Bills in the divisional round.

[233] In a rematch of Super Bowl LVII against the Eagles, Mahomes struggled mightily, throwing for 33 yards, two interceptions (one returned for a touchdown), and a passer rating of 10.7 in the first half.

[234][235] Mahomes put up most of his positive statistics after the game was out of reach, finishing with 257 yards, three touchdowns, three turnovers, and a career-high six sacks as the Chiefs lost 40–22.

[261] Ahead of Super Bowl LVII, which was the first Super Bowl to feature two black starting quarterbacks as the Chiefs faced off against Jalen Hurts and the Philadelphia Eagles, Mahomes acknowledged that his creative playing style was inspired by that of Negro league baseball players, especially Satchel Paige, who likewise inspired his father's baseball playing style.

Number one overall draft picks Kyler Murray and Bryce Young are regarded as examples of this effect, with the two being highly touted prospects despite lacking traditional size for the position.

[281] In addition, he has signed endorsement deals with Oakley,[282] Essentia Water, Hy-Vee,[283] State Farm,[284] DirectTV,[285] Adidas,[286] and Head & Shoulders.

[298] Following the murder of George Floyd by police officer Derek Chauvin, Mahomes, along with teammate Tyrann Mathieu and several other NFL players, made a video encouraging the NFL to condemn police brutality and violence against black people and to admit it was wrong to silence Colin Kaepernick and Eric Reid for their protests during the playing of the National Anthem.

[310] As of June 2024, there are 14 Whataburger locations in the Kansas City area, with Mahomes's investment group, called KMO Burgers, operating 11 of them.

[311] In 2024, Mahomes, along with the rest of the ownership group of the Current, expressed interest in bringing a WNBA expansion franchise to Kansas City.