Andrzej (Andrew) Pohorille (May 14, 1949 – January 6, 2024)[1] was a Polish-American astrobiologist, biophysicist, and quantum chemist who worked mostly at the NASA-Ames Research Center and University of California, San Francisco.

[2][3][4] His work proposed that proteins may have been the first molecules to support life, challenging RNA-first theories of abiogenesis.

[9] He went on to conduct postdoctoral research at the Institut de biologie physico-chimique in Paris, where he worked in the group of Bernard Pullman.

He moved to the University of California, San Francisco in the same year as a professor at the Department of Pharmaceutical Chemistry.

Pohorille was married to Joanna Sokołowska, whom he met at a conference and is also his working partner.