He attended the General Theological Seminary and Columbia University in New York following the beginning of his ministry in China,[2] receiving a BD from GTS in 1909.

He was consecrated on May 1, 1940, in Holy Trinity Cathedral, Shanghai as assistant bishop to Ronald Owen Hall of the Anglican Diocese of Hong Kong; his co-consecrators included Daniel Trumbull Huntington and Francis Lushington Norris.

"Yunnan-Kweichow" was shorted to "Yun-Kwei," but during World War II, Tsu was known informally as "Bishop of the Burma Road".

Following his 1946 appointment as General Secretary of the Chung Hua Sheng Kung Hui,[2] Tsu was succeeded as "Bishop for Yun-Kwei" by Quentin Huang, consecrated on August 14, 1946, in Santa Barbara, California.

With the advance of Communism in China, he lived in exile in the United States from 1951.