He founded the Waterboer dynasty of Griqualand West, and led to a split of the Griqua people, as the factions of the Kok and Barends dynasties migrated to the south east to later found Griqualand East.
Unlike the majority of the predominantly mixed Griqua people, Waterboer was of pure Bushman origin, and seems to have been born in the wilderness somewhere north of the Gariep, probably in the late 1700s.
He joined the house of the powerful ruling family of the Griquas, the Koks, took the name of "Andries Waterboer" and learned to read and write.
Eventually Waterboer defeated the Bergenaars, Koranas and other Griqua factions, and consolidated his rulership.
In 1823, in alliance with the Koks and Barends dynasties, he won the battle of Dithakong, and thereby diverted the great Mfecane migrations from Griqua territory.