Andritsaina flourished during the Frankish rule (13th-14th centuries AD) and is mentioned in the Chronicle of the Morea.

The village played a crucial role during the Orlov Revolt and the Greek War of Independence.

Today, the village has impressive old mansions, cobblestone streets, a square surrounded by tall trees and magnificent views.

The famous Nikolopouleios library was founded in 1840 from donations of the humanist Agathofron Nikolopoulos, whose family came from Andritsaina.

The famous Temple of Epicurian Apollo at Bassae is 6 km south of Andritsaina, in Messenia.