With the start of the Greek War of Independence, Anagnostopoulos, though he was friendly to the wing of Maurokordate, penetrated in the alliance of Alexander Ypsilantis, whom he had escorted on his arrival in Peloponnese.

In 1828 Anagnostopoulos was assigned by Kapodistrias temporary commissioner-governor (prefect of Ilieia), while later he took other political positions such as that of Euboia's administrator and governor of Achaia and Ilidos.

Anagnostopoulos, in an unpublished article, with the title "General Observations" criticized Xanthos for not being in the founding members of Filiki Eteria and accuses him of financial malpractices.

The truth about who was initiated first in the Filiki Eteria is of this day unknown since the opinions of historians are divided, while the archived documents are few and sometimes unreliable to answer with certainty.

Anagnostopoulos died in 1854 in Athens from cholera, brought to Greece by the English-French army occupying Piraeus during the Crimean War.