[5][6] From 23 January to 23 February 2014, amidst the escalation of Euromaidan into the Revolution of Dignity, he worked as the head of the Presidential Administration of Ukraine.

[7] In June 2009, the Klyuyev brothers were ranked 48th in the Korrespondent's list of Top 50 richest Ukrainians with the estimated wealth of US$227 million.

[citation needed] From 1991 to 1994, Klyuyev headed several coal mining-related machine building companies, including "Ukrpidshipnyk" SC.

[15] Klyuyev has been repeatedly accused by journalists of being "a shadowy oligarch"[16] with business links to (former President) Viktor Yanukovych's family, allegedly using his power to secure multi-billion contracts.

[14] Just prior to the Maidan revolution, Andrii and Serhiy Klyuyev sold their shares in Vienna based Activ Solar GmbH and Clean Economic Energie (CEE) AG, which is a holding company that operates solar power plants in Crimea with 380 MWp capacity and 500 MWh annual production.

From November 1995 to April 1996 he was a Deputy Head of the Donetsk Oblast State Administration, responsible for local development, trade, and consumer goods production.

[citation needed] After a career in Donetsk Oblast, and at the time working closely with later and current President Viktor Yanukovych, Klyuyev moved to national politics.

[25] On 24 January 2014, President Yanukovych signed a decrees that dismissed Klyuyev as National Security and Defense Council secretary and appointed him head of the Presidential Administration of Ukraine.

[2] His spokesman, Artem Petrenko, claimed 2 days later that Klyuyev's had been wounded when his car had been attacked while he was travelling back to Kyiv from Crimea after tendering his resignation to former President Yanukovych.

[32][33] For his roles in destabilizing Ukraine, his role in the Victor Yanukovych government, his support for pro-Russia individuals and entities in Ukraine, abuse of office, and for embezzlement of public funds, Klyuyev is under sanctions by Switzerland since 26 February 2014, by Lichtenstein since 3 March 2014, by the European Union since 6 March 2014,[34] by Canada since 20 July 2015,[35] and by the United States, also since 30 July 2015.