After a period of three years (after the dissolution of the Soviet Union), the family moved back to their native country and settled in the city of Chernihiv.

[9][10] In 2007, Yarmolenko signed a five-year contract with Ukrainian club Dynamo Kyiv, where he joined its second team, Dynamo-2, which plays in lower leagues, for a couple of seasons.

In a match in October 2015, Yarmolenko committed a dangerous challenge which almost broke Shakhtar Donetsk player Taras Stepanenko's leg.

[18] On 11 July 2018, Yarmolenko signed for Premier League club West Ham United on a four-year contract for an undisclosed fee.

On 31 August 2019, he scored his first goal since his return from injury, doubling West Ham's lead with a left-footed volley in a 2–0 win over Norwich City.

[26][27] On 25 November 2021, Yarmolenko scored against Rapid Wien at the Allianz Stadion and provided the penalty for the 2–0 away win for West Ham in the UEFA Europa League group stage.

[29] He returned on 13 March, substituting an injured Michail Antonio and scoring the opening goal in a 2–1 victory over Aston Villa.

On 5 September 2009, in the 2010 FIFA World Cup qualification game against Andorra, Yarmolenko made his first senior appearance for Ukraine and scored in a 5–0 win.

Yarmolenko scored a hat-trick on 15 November 2014, netting all of Ukraine's goals in a 3–0 victory away to Luxembourg in UEFA Euro 2016 qualifying.

[35] In November 2015, Yarmolenko scored in both legs of Ukraine's 3–1 play-off victory over Slovenia to qualify the nation for Euro 2016 final stages.

The only goal of the game, he deflected a free-kick by Gareth Bale past goalkeeper, Heorhiy Bushchan as Wales qualified for their first World Cup since 1958.

[50] In 2020, Dmitry Adehiro created a mural with the image of Yarmolenko, during the reconstruction of the building of the Yunost Youth Sports School, just beside the Yunist Stadium in Chernihiv.

He also flew to the Ukraine border to rescue his wife and child after they fled the country following the invasion, according to former Ukrainian international Andriy Shevchenko.

The striker of the national team of Ukraine and Benfica, currently playing for Olympiacos (Greece), Roman Yaremchuk told how his wife's parents were able to be taken out of Chernihiv with the help of Andriy Yarmolenko.

Mark Noble was in tears as the Hammers beat Sevilla to reach the Europa League quarter-finals on this famous night.