In 2014, he started a solo music project under the moniker Andy Black and released his debut album, The Shadow Side, in 2016.

This bullying is reenacted in the "Knives and Pens" music video,[3] performed by his band, Black Veil Brides.

Two days after he turned 18, he left school before graduating to move to Los Angeles in hopes of furthering his potential career.

[10] On May 19, 2014, he premiered his first song, titled "They Don't Need to Understand", online with a music video via Hot Topic.

[13] In February 2016, Biersack was cast to play the role of Johnny Faust in the independent supernatural thriller film American Satan alongside Asking Alexandria member Ben Bruce.

[17] Biersack wrote They Don't Need to Understand: Stories of Hope, Fear, Family, Life, and Never Giving In with longtime journalist Ryan J. Downey, which arrived in December 2020.

[18] From 2020 to 2021, Biersack voiced Batman in a web-series adaptation of the DC Comics mini-series Dark Nights: Death Metal.

I always fight with that, because I would love nothing more to believe that my grandfather is in the clouds playing "Xbox 460" [sic] or whatever awesome stuff they have up in Heaven, but I can't.

[21] On October 30, 2016, Biersack was involved in a physical altercation with his wife, Juliet Simms, on a flight back to Los Angeles.

According to the video testimony given by adult film actress Mary Carey, a witness to the incident, Simms forcibly struck Biersack in the face twice.

Carey also stated Simms struck herself in the face with the airline handcuffs until her nose began to bleed, alleging that she was defending herself against Biersack.

[23][24] Biersack has suffered multiple injuries while performing with Black Veil Brides, most notably his fall from a 15-foot (4.6 m) pillar on June 18, 2011, in Hollywood.

In an attempt to jump back onto the stage, he fell forward and hit his ribcage, knees and skull on the edge, which resulted in three ribs shattered, and one displaced.