Shortly after his breakthrough with "Gump", Comeau appeared as Charlie in 8 Heads in a Duffel Bag (1997) alongside Joe Pesci, David Spade and Kristy Swanson.

He also guest-starred in Criminal Minds in the season 1 episode "Charm and Harm" where he played a serial killer named Mark Gregory who abducted random women before holding them prisoner for several days while subjecting them to torture before drowning them.

In 2010, Comeau portrayed a plastic surgery patient in the final season of Nip/Tuck and appeared in a Progressive Auto Insurance advertisement.

Comeau's theater credits include The Cherry Orchard, Biloxi Blues, The Tempest and A Midsummer Night's Dream.

He is the bandleader and saxophonist for the Los Angeles-based band Vaud and the Villains, a 19-piece New Orleans 1930s themed musical act with dancers and spoken word artists.