McCullough attended Meadowdale High School in Dayton, Ohio, where he excelled in both football and basketball.
[5] Scouts, and fans traveled to Dayton Ohio from all over the country to watch McCullough play ball.
He finished out his junior year fourth on the Tennessee team with a total of 352 yards receiving in 24 catches and four touchdowns.
[7] He was part of the Vols 1997 SEC Championship.In the Orange Bowl that year, he caught a 29-yard pass, the team's longest reception.
McCullough earned World Bowl MVP honors as the Galaxy captured the NFL Europe League championship.
[14] He was the star of the game catching six passes for 151 yards and scored three touchdowns in Frankfurt's 38–24 win over the Barcelona Dragons.
[16][17] The Kansas City Chiefs signed him to the 2000 NFL season McCullough also spent time with the Tennessee Titans.
In 2001, McCullough was signed by the Oakland Raiders and allocated to the NFL Europe League where he played, again, for the Frankfurt Galaxy.
McCullough received yet another game MVP with his performance in Los Angeles when he experienced the first two interceptions of his career.
McCullough also was named game MVP against Chicago, when he scored two touchdowns and caught seven passes for 118 yards.
He was named Ironman of the Game in the first round of the playoffs against Indiana when he led the team with 99 yards on nine catches and scoring three times.
[27] The Gladiators released him in 2008 due to a broken hand, suffered during his time in the NFL, that never healed properly.
in Dayton, he averaged 29 points to lead the state of Ohio in scoring and was named second-team All-State as a basketball player.
McCullough helped lead his Ohio team to victory before some 16,000 fans at Hersheypark Stadium after quarterback Scott Mutryn's 74-yard completion to Tennessee-bound Andy McCullough set up Curtis Enis' 1-yard touchdown run for the game's first score with 1:33 left in the first quarter.
As a split end, McCullough caught 35 passes for 595 yards and 10 touchdowns and defensively, registered 95 hits, including 10 sacks and 11 tackles for a loss as a senior.
He was named city champion in his senior year and was a member of the number one recruiting class at Tennessee.