Andrew William Van Hekken (born July 31, 1979) is an American former professional baseball pitcher.

In his first Major League appearance, he threw a complete game shutout for a victory against the Cleveland Indians.

From 2005 to 2011 he has pitched for Cincinnati Reds, Atlanta Braves, Florida Marlins, Kansas City Royals and the Houston Astros.

On April 17, 2018, Van Hekken signed with the New Britain Bees of the Atlantic League of Professional Baseball.

He left the team on August 14, 2018, to sign with the Uni-President Lions of the Chinese Professional Baseball League.