On television, in 2024, he won the eighteenth series of Taskmaster against Babatunde Aléshé, Emma Sidi, Jack Dee, and Rosie Jones.

[2] Zaltzman first performed at the Edinburgh Festival Fringe in 1999, when he was a finalist in the prestigious So You Think You're Funny new act competition along with Josie Long, Russell Howard and David O'Doherty.

[3] His debut full-length Edinburgh Fringe show Andy Zaltzman versus the Dog of Doom received a nomination for Best Newcomer at the Perrier Comedy Awards in 2001.

[citation needed] Zaltzman performed at the Melbourne International Comedy Festival for the first time in April 2007, winning the coveted Piece of Wood Award, given to the best show as voted for by other comedians.

[6] Since mid-2014 Zaltzman has toured Satirist for Hire, where questions and comments are solicited from potential or confirmed audiences (usually via email or social media) before performing at venues, giving parts of the show a constantly evolving order and structure.

Also featuring Rory Bremner and Bridget Christie, the show contained stand-up and sketches focusing on the last 10 years.

More recently he has appeared on Test Match Sofa's successor www.guerillacricket.com and was an occasional member of the team when they broadcast the programme from a central London sports bar for the 2015 Ashes.

[8] In 2017 he wrote and performed a three-part series on ancient philosophy including Stoicism, Epicureanism and Cynicism for BBC Radio 4.

[17] In 2018, along with comedian and occasional The Bugle co-host Anuvab Pal, he wrote and performed in Empire-ical Evidence, a look at the rise and fall of the British Empire produced for BBC Radio 4.

[23] In November 2024 Zaltzman won the eighteenth series of Taskmaster, beating Babatunde Aléshé, Emma Sidi, Jack Dee and Rosie Jones.

[25] In June 2007, BBC2's The Culture Show commissioned Zaltzman and John Oliver to write a mock farewell speech for departing Prime Minister Tony Blair.

[27] Zaltzman played the host of The Bug podcast in 2020's Watch Dogs: Legion, alongside his Bugle co-host Alice Fraser.

[28] Zaltzman is a huge fan of cricket and in November 2008 began a regular blog for Cricinfo, named "The Confectionery Stall" after a famous piece of commentary by Richie Benaud, where he described a shot by Ian Botham during his innings at the third Ashes Test Match at Headingley, in 1981 as having "gone straight into the Confectionery Stall and out again".