The podcast began in Zaltzman's living room in Crystal Palace, London, with assistance from Martin Austwick (a.k.a.

In 2009, Zaltzman and Mann made history by being the first podcasters to be given their own national show on BBC Radio 5 Live, Web 2009 with Helen and Olly.

The Last Post, Jordan, Jesse, Go!, The Chuck Tingle Podcast, Hello from the Magic Tavern, Ologies, 99% Invisible, Potterless[13] and ZigZag.

[16] In May 2013, Zaltzman began hosting a monthly podcast for Sound Women, an organisation which campaigns against sex discrimination in the radio industry.

[17][18] In September 2020, Zaltzman hosted the Duocon 2020 Livestream, a world-wide live conference for the language learning platform Duolingo.

She has created props, including a giant inflatable Boggle set; dinosaur costumes; and dolls of Tony Benn, Robert Plant, and Donald Rumsfeld.

[22] Zaltzman has acted in plays at the Edinburgh Festival Fringe, and will occasionally perform live comedy, most often with Josie Long and Robin Ince.

[26] She grew up in Tunbridge Wells and won a scholarship to Sevenoaks School, then studied English at St Catherine's College, Oxford.