The club, established in 1879, currently plays in the Barossa Light & Gawler Football Association.

Angaston was a founding member of the Barossa & Light Football Association (BLFA), predecessor of the current league, in 1908.

In the early 1900s, Angaston won six premierships until 1915 when World War I broke out and suspended football.

The Angaston Panthers FC holds the record for being the only club to have drawn twice in a Grand Final, the first in 1969 against Nuriootpa F.C.

The Angaston Football Club still continues to field junior and senior teams in the Barossa Light & Gawler Football Association and has won the most premierships in the former BLFA but have only won one premiership in the current league.