[3] Her family moved from Seneca, South Carolina to Maryland in July 1956 shortly after her great-grandfather, J. C. James, was shot and killed by police officer Charles Lee[4] while resisting arrest.

[9][11] After she was admitted to the Maryland Bar in 1996,[12] Alsobrooks clerked for law firms DLA Piper and DeCaro, Doran, and for Circuit Court Judges William D. Quarles Jr. and Donna Hill Staton until 1997,[13][14] when she began working as an assistant state's attorney in Prince George's County, where she was assigned to handle domestic violence cases.

[40] She also divided her office's prosecutors into the county's six police districts to handle cases specific to each region, and concentrated on addressing quality-of-life concerns, discouraging truancy, and increasing social services.

[15] During the primary, Alsobrooks was endorsed by The Washington Post,[47] U.S. senator Chris Van Hollen, U.S. representatives Anthony Brown[48] and Steny Hoyer, and numerous labor unions.

[49] Alsobrooks won the Democratic primary election with 61.8% of the vote,[50] defeating eight other candidates, including former Congresswoman Donna Edwards and state senator C. Anthony Muse.

[65] In July 2019, Alsobrooks traveled to Detroit, Michigan to lend moral support to Kamala Harris during one of the televised presidential debates, bringing her teenage daughter along.

In May 2020, as hospitalizations began to plateau statewide, Alsobrooks expressed concern with the state's potential plans to begin easing some COVID-19-related restrictions, citing health department reports showing that the county was still dealing with a surge in COVID-19 patients.

[86] She also joined almost every other county executive in sending a letter to Maryland Governor Larry Hogan warning that their jurisdictions "lack sufficient resources" to take steps to reopen in the weeks ahead.

[65] During the Democratic primary, she ran on a platform emphasizing "kitchen-table" issues, such as community safety and health care, while also focusing on her political career as a prosecutor and county executive.

[112][113] She received several high-profile endorsements from the Maryland Democratic political establishment early in her candidacy, including from Chris Van Hollen,[114] Steny Hoyer,[115] Wes Moore,[116] and multiple state legislators and county executives.

[75][139] In one of her first cases as state's attorney in February 2011, Alsobrooks sought the death penalty against Darrell Lynn Bellard, who had killed four people, including two children, in Prince George's County.

[150] In 2014, after the Maryland General Assembly voted to decriminalize the possession of small amounts of marijuana, Alsobrooks formed a committee to develop a plan on how to handle marijuana-related offenses.

[152] In November 2015, Alsobrooks controversially claimed on WAMU's The Kojo Nnamdi Show that the decriminalization of marijuana resulted in a 30% increase in murders in Prince George's County.

[157] In November 2016, Alsobrooks spoke in support of a proposed rule prohibiting prosecutors from setting a high bail on poor defendants,[158] arguing that the change would provide equal protection under the law for low-income individuals.

[176] Following a large teen brawl at National Harbor in April 2024, Alsobrooks declared a state of emergency and signed an executive order reinstating the youth curfew.

[185] In March 2023, Alsobrooks joined Democratic members of Maryland's congressional delegation and Governor Wes Moore in co-signing a letter to President Joe Biden asking him to get involved in the FBI's headquarters selection process.

[188] In April 2023, she expressed concerns with a bill to provide rental assistance to low-income residents, saying she wanted to wait for long-term recommendations from a housing work group.

[193] In October 2015, Alsobrooks said she supported a bill that required Prince George's County businesses to provide employees up to seven days of paid sick leave annually.

[213] After ethics charges were filed against almost all members of the Prince George's Board of Education in August 2021, Alsobrooks asked the state's top school officials to "immediately" investigate the allegations.

[219] During her 2024 U.S. Senate campaign, Alsobrooks supported expanding the federal Pell Grant program and said she would work with the Biden administration to provide student loan relief.

[246] She later expressed support for a ceasefire in the war alongside the release of hostages held by Hamas,[244][247] and argued that the U.S. should withhold its offensive weaponry to Israel if it invades Rafah.

[156] She has also described Russian President Vladimir Putin as a dictator and a tyrant, and expressed frustration with Republican efforts to hold up bills providing military assistance to Ukraine.

[253] During her 2024 U.S. Senate campaign, Alsobrooks supported capping the price of insulin at $35, protecting Social Security,[250][7] and expanding the Affordable Care Act and Medicaid to ensure universal health coverage.

[257] In October 2012, Alsobrooks spoke against Question 4, a ballot referendum that sought to repeal Maryland's Dream Act, a bill that extended in-state tuition to undocumented immigrants.

[240] She supported the Bipartisan Border Security Bill negotiated by Senators James Lankford and Kyrsten Sinema and blamed former President Donald Trump for its failure to pass.

[265] In January 2019, she announced a relief package for federal workers impacted by the shutdown, which included funds for food and rent assistance, student financial aid, and utilities.

[282] In April 2023, Alsobrooks agreed with proposals to create a $2 million universal basic income pilot program in Prince George's County but expressed concerns with its funding due to its tight budget constraints.

[283] The $4 million pilot program, which was funded using a public-private partnership and provided $800 monthly payments to 125 seniors over a two-year span, was unanimously passed by the county council and launched in November.

[287] In May 2021, she sent a letter to Acting Federal Railroad Administrator Amit Bose and Maryland Transportation Secretary Greg Slater to voice her opposition to the D.C.–Baltimore maglev proposal,[288] arguing that the construction would "tear through environmentally sensitive areas" and that the 311-mile-an-hour train would cause vibrations and hurt property values.

[294] During her 2024 U.S. Senate campaign, she criticized former Governor Larry Hogan's cancellation of the Red Line in Baltimore and promised to support transit projects in the city, calling it the "foundation of economic opportunity".