Her first contract was at the Theater Ulm (1992–1996), where she sang Fiordiligi (Così fan tutte), Donna Anna (Don Giovanni) and Agathe (Der Freischütz), among other roles.
Angela Denoke sang also the title role in Der Rosenkavalier at the Theater Ulm, in a production directed by Peter Pikl and conducted by James Allen Gähres, in September 1994.
She regularly sings at all the major opera companies in the world; in Berlin, Hamburg, Dresden, London, Paris, San Francisco, and Chicago.
[3] In 2006, she sang the title role in Richard Strauss' Salome at the Bayerische Staatsoper, directed by William Friedkin and conducted by Kent Nagano.
In opera and in concerts, Denoke worked with conductors such as Claudio Abbado, Daniel Barenboim, Sylvain Cambreling, Christoph Eschenbach, James Allen Gähres, Hartmut Haenchen, Zubin Mehta, Ingo Metzmacher, Kent Nagano, Seiji Ozawa, Mikhail Pletnev, Sir Simon Rattle, Donald Runnicles, Esa-Pekka Salonen, Giuseppe Sinopoli, Stefan Soltesz and Christian Thielemann.