Angelic acid esters are the active components of herbal medicine used against a wide range of various health disturbances including pains, fever, gout, heartburn, etc.

These plants include Angelica archangelica, Peucedanum ostruthium (masterwort), Levisticum officinale (lovage),[2][3] Euryangium sumbul and Laserpitium latifolium.

Angelates of alkaline earth metals M have a general formula M(C5H7O2)2 and form white, water-soluble crystals.

[9] The angelic acid esters of sesquiterpene alcohols, such as petasin, are the active chemical behind the strong pain-relieving and spasmolytic action of extracts from the plant butterbur.

[2] Roman chamomile, in which esters of angelic and tiglic acids are the principal components, was used as a sedative and tonic, and as a medicine against nervous problems, fever, colic, heartburn, loss of appetite, gout, headache and other health disturbances.