With the support of her father, she played a small character in the telenovela El amor tiene cara de mujer in 1971, produced by Televisa and directed by German director Fernando Wagner.

It was through Juan Ribó that Aragón met the actor, director and playwright Alejandro Jodorowsky, participating as an extra in the film La montaña sagrada (1973).

Returning to Mexico in 1980, Aragón joined the Mexican telenovelas of Televisa with the producer Valentín Pimstein, whom she met through the Greek director Dimitrio Sarrás.

In 1986, the producer and director Carlos Téllez offered Aragón the starring role in the hit telenovela Cuna de lobos, but she rejected it, being replaced by Diana Bracho.

She also made a special appearance in the telenovela En carne propia, produced by Carlos Téllez, starring alongside Edith González and Gonzalo Vega.

In that same year, she played "Chole", an indigenous Zapotec woman in the telenovela De frente al sol, produced by Carla Estrada, costarring with the actress María Sorté.

In 1996, Aragón appeared in the telenovela Cañaveral de pasiones, produced by Humberto Zurita and Christian Bach, and starring Daniela Castro and Juan Soler.

In 1997, the company Argos Comunicación offered Aragón the starring role in the telenovela Mirada de mujer, a Mexican adaptation of the Colombian novel Señora Isabel by Bernardo Romero Pereiro.

The story of María Inés Domínguez, a mature woman in love with a younger man, brought Aragón the greatest success of her television career in a telenovela that breaks contemporary stereotypes in Mexico.

Aragón starred alongside Ari Telch, Fernando Luján, Margarita Gralia, Evangelina Elizondo, and an important cast of supporting actors.

In 1984, Aragón made her debut in films in The Evil That Men Do with Charles Bronson, produced by Pancho Kohner (son of Mexican actress Lupita Tovar) and J. Lee Thompson.

Due to her participation in a Mexican telenovela, Aragón had to decline the actor and director Robert Redford's invitation to co-star with him in the film The Milagro Beanfield War.

She then appeared in other Mexican productions like Lamberto Quintero (1987) alongside the folk singer Antonio Aguilar; Sabor a mí (1988) with the singer Jose Jose, inspired by the life of the Mexican composer Alvaro Carrillo; La furia de un dios (1988), by Felipe Cazals, alongside Humberto Zurita and Assumpta Serna, and Goitia: un dios para si mismo (1989), by Diego López Rivera, inspired by the life of the painter Francisco Goitia, among other films.

At the beginning of the following decade, Aragón appeared in films like Pueblo de madera (1990), by Juan Antonio de la Riva, with Mario Almada and Gabriela Roel; Gertrudis (1992), based on the life of the Mexican political activist Gertrudis Bocanegra, with Ofelia Medina; the American production The Harvest with Miguel Ferrer and George Clooney; La señorita (1994), by Mario Hernández, with Jacqueline Andere and María Rojo, and Novia que te vea (1994), by Guita Schyfter, for which she received her first Silver Ariel Award for Best Supporting Actress.

In that same year she won her second Silver Ariel Award as best supporting actress for her role in the film Cilantro y perejil, alongside Demián Bichir and Arcelia Ramírez and directed by Rafael Montero.

[7] In 2002, she appeared in the controversial and successful film by Carlos Carrera El crimen del Padre Amaro next to Gael García Bernal, for which she won the third Silver Ariel Award of her cinematographic career.

In the 2010s, Aragón acted in films like Cinco de mayo: La batalla (2013), again with actor Kuno Becker; the Spanish-Mexican co-production Todos están muertos (2014), by the filmmaker Beatriz Sanchiz, sharing a scene with Elena Anaya and Patricia Reyes Spíndola, and Treintona, soltera y fantástica (2016), starring Barbara Mori.

[8] Aragón began her acting career in various student theater projects at the Festival Cervantino in Guanajuato and at the Teatro de la Alianza Francesa.

After meeting Alejandro Jodorowsky, Aragón had a small role in the play Zaratustra (1970), also featuring Héctor Bonilla, Carlos Ancira and Isela Vega.

[10] Having received artistic training in the United Kingdom that included music, Aragón released a record titled Silencio corazónin 1997, born with the intention of preserving the compositions of her father, José Ángel Espinoza or "Ferrusquilla".

In 2010, on the occasion of the bicentennial of Mexican independence, Aragón released a third album titled México: mi palabra más bella, produced by her father.

For several years, she has been part of the campaign known as Lectura en voz alta, responsible for promoting reading with children and adults in rural regions of Mexico.