As a young man he felt called to the religious life and persevered in this early vocation in spite of the desire of his parents to have their only son study law or medicine.

In 1639 he was appointed professor of belles-lettres, at the convent of St. Stephen in Venice, and subsequently Vicar general of the Congregation of Santa Maria della Consolazione in Genoa.

The Aprosian Library housed over ten thousand volumes and was officially recognized in 1653 by Pope Innocent X, who issued a ban prohibiting the sale of any of its books and opened it to the public.

[6] Aprosio was a member of several academies and learned societies, including the Incogniti of Venice, [7] the Apatisti of Florence, the Geniali of Codogno, the Ansiosi of Gubbio, the Infecondi of Rome, and the Eterocliti of Pesaro.

Raffaele Soprani, who knew him personally, says that he had no equal in his knowledge of authors, ancient and modern; and adds that he himself is much indebted to him for contributions to his own work on the writers of Liguria.