His father Giuseppe Frari came from Treviso to Sebenico, where he became the chief municipal physician and the author of the first work on rabies written in Dalmatia, published in 1782 in Ancona: Riflessioni teorico-mediche sopra una grave malattia, l'istoria della quale farà vedere li sintomi che precedettero (...) (Ancona, Presso Pietro Ferri 1783).
Frari graduated in medicine from the University of Padua in 1801 and acquired further medical education in Vienna as a student of the famous public health ideologist and founder of hygiene as a science, Dr Johann Peter Frank.
He also incited the launching the new Law on Health Issues, which was officially accepted in 1812, together with the Instructiones sur les Lazarets, which were mostly composed by Frari.
During this period of his life, Frari was also very effective in the suppression of plague epidemics in Spalato, Makarska, and in some regions of Montenegro and Albania.
Tommaseo, on Frari's proposal, even wrote a letter of protest to the Austrian Emperor regarding poverty and poor sanitary conditions in Dalmatia.
Frari was awarded the Gold medal of civilian merit honor for services rendered in plague circumstances (medaglia d'oro di onore del merito civile per servizi prestati in circostanze di peste) by the Emperor Franz Joseph I of Austria for his epidemiologic work in Dalmatia.