Shortly after his brother's death in August 1458, Pope Pius II named him governor of Bologna in September 1458.
[1] In the consistory celebrated in Siena on 5 March 1460, Pope Pius II made Capranica a cardinal priest.
[1] On 23 November 1471 the new pope named him papal legate to the Italian princes for the purposes of a new crusade against the Ottoman Turks.
[1] On 11 December 1472 Angelo became a cardinal bishop, taking the suburbicarian see of Palestrina, though retaining his titulus of Santa Croce in Gerusalemme in commendam.
[1] He celebrated a synod there, but soon fell ill and returned to Rome on 17 November 1473, resigning the archbishopric on 17 June 1474.