He painted icons in the maniera greca, at a time when that style was moving away from the traditions of the Byzantine Empire and towards the more refined aesthetic of the Cretan school.

Akotantos taught painting to Andreas Pavias, Andreas Ritzos, and Antonios Papadopoulos, and his style influenced later artists such as Georgios Klontzas, Theophanes the Cretan, Michael Damaskinos and El Greco.

Much information about Angelos's life is drawn from the will he composed in 1436, in advance of a planned journey to Constantinople.

He specified that if his child died young the books in this library should be sold and the money raised should go to charities of his choice.

[8] He was familiar with the monastic superior of Saint Phanourios at Versamonero, and the will grants the institution a sum of money to hold memorial services after his death.