Angiopellosis was discovered by studying the way that stem cells reach damaged tissue when injected or infused into the circulatory system.
[1] It has been found that circulating tumor cells (CTCs) possess this ability to exit blood vessels through angiopellosis during the process of metastasis.
Angiopellosis was first observed by researchers studying the mechanism by which intravenously injected stem cells arrived at damaged tissue.
Studies show that these clusters are capable of exiting blood vessels through angiopellosis while maintaining their multicellular configuration, thus enhancing their ability to establish secondary tumors.
[9] This cluster-based migration and extravasation may contribute to the increased treatment resistance observed in metastases, as CTC clusters can harbor a greater diversity of cell types than single CTCs.