Anguilla is a town in Sharkey County, Mississippi, United States.

[3] According to the United States Census Bureau, the town has a total area of 1.0 square mile (2.6 km2), all land.

As of the 2020 United States Census, there were 496 people, 254 households, and 154 families residing in the town.

The racial makeup of the town was 77.8% African American, 21.2% White, 0.1% Asian, and 0.7% from two or more races.

The town of Anguilla is served by the South Delta School District.